EliKine™ Rat VEGF ELISA Kit

VEGF-A gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of VEGF-A gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for VEGF-A gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.

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SPECIFICATIONS

Catalog Number

KET9008

Size

48T, 96T, 96T*5

Applications

ELISA

Reactivities

Rat

Gene Id

83785

Accession

P16612

Additional Info

EliKineв„ў Rat VEGF ELISA Kit has high sensitivity and excellent specificity for detection of Rat VEGF-A. No significant cross-reactivity or interference between Rat VEGF-A and analogues was observed.