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Cleaved-Caspase-9 (D353) Polyclonal Antibody

Cat no: ABP50009

Cleaved-Caspase-9 (D353) Polyclonal Antibody

CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. Caspase 9 is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

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SPECIFICATIONS

Catalog Number

ABP50009

Size

30micro l, 100micro l, 200micro l

Applications

ELISA, IF, IHC-F, WB

Hosts

Rabbit

Reactivities

Mouse, Rat

Gene Id

842

Isotype

Rabbit IgG

Accession

P55211

Clonality

Polyclonal

Concentration

1 mg/ml

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