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Catenin-? Monoclonal Antibody

Cat no: ABM40192

Catenin-? Monoclonal Antibody

The protein encoded by CTNNB1?catenin beta 1) is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1.

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SPECIFICATIONS

Catalog Number

ABM40192

Size

30micro l, 100micro l, 200micro l

Applications

IF, IHC-F, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Gene Id

1499

Isotype

Mouse IgG1

Accession

P35222

Clonality

Monoclonal

Concentration

1 mg/ml

SUPPLIER INFO

Abbkine Scientific Co.Ltd.

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