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Anti-Cyclophilin B Monoclonal Antibody (7B2), AbFluor™ 647 Conjugated

Cat no: A01130A647

Anti-Cyclophilin B Monoclonal Antibody (7B2), AbFluor™ 647 Conjugated

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.

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SPECIFICATIONS

Catalog Number

A01130A647

Size

100micro l

Applications

IF, IHC

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Gene Id

5479

Isotype

Mouse IgG

Accession

P23284

Clonality

Monoclonal

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