ZNF271 antibody - N-terminal region (ARP35804_P050)

Size

50ug

Hosts

Rabbit

Format

Lyophilized powder

Target

ZNF271 may be involved in transcriptional regulation. It plays a role in the EBV-mediated transformation process.Zinc finger proteins interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM]. Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene, CASP12, is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-360 AF464191.1 1-360 361-459 AP002004.4 93094-93192 c 460-967 AF464191.1 460-967 968-968 AP002004.4 86300-86300 c 969-1306 AF464191.1 969-1306

Gene Id

10778