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ZEB1 Antibody (OAPB01132)

ZEB1 Antibody (OAPB01132)

ZEB1, initially identified as the delta-crystallin enhancer binding protein delta EF1, is a DNA-binding protein that binds to a modified E-box sequence and has been implicated in postgastrulation embryogenesis. ZEB1 binds to the promoter of several hemapoietic genes, including interleukin-2, CD4, GATA-3, and alpha(4)-integrin, and mice in which ZEB1 has been targeted show thymic atrophy, and severe defects in lymphocyte differentiation. Recent evidence suggests that ZEB1 also regulates the accumulation of adipose tissue and may play a role in obesity. Mutations in this gene have been associated with late-onset Fuchs endothelial corneal dystrophy.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, ICC, WB

Hosts

Rabbit

Reactivities

Hum

Presku

OAPB01132

Target

Zinc finger E-box binding homeobox 1

Alternative Names

ZEB1;Zinc finger E-box binding homeobox 1; BZP; TCF8; AREB6; FECD6; NIL2A; ZFHEP; ZFHX1A; DELTAEF1

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