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YWHAQ (Human) cDNA (1ug)

YWHAQ (Human) cDNA (1ug)


Supplier: Aviva Systems Biology Incorporated
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The ORF of human YWHAQ is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-YWHAQ polyclonal antibody.
Presku: ANA11435
Size: 1ug
Gene: 10971
Target: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.