WW domain-containing o, Xenopus/Amphibian,idoreductase (WWO, Xenopus/Amphibian,) is a putative o, Xenopus/Amphibian,idoreductase. WWO, Xenopus/Amphibian, is a tumor suppressor and plays a role in apoptosis. WWO, Xenopus/Amphibian, acts synergistically with p53/TP53 to control genoto, Xenopus/Amphibian,ic stress-induced cell death. WWO, Xenopus/Amphibian, plays a role in TGFB1 signaling and TGFB1-mediated cell death. WWO, Xenopus/Amphibian, also play a role in tumor necrosis factor (TNF)-mediated cell death. WWO, Xenopus/Amphibian, is required for normal bone development.