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Wibg (within bgcn homolog (Drosophila) ) Blocking Peptide (the middle region of Wibg)(100ug)

Wibg (within bgcn homolog (Drosophila) ) Blocking Peptide (the middle region of Wibg)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Wibg Antibody (ARP60532_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human, Mouse
Presku: AAP60532
Size: 100ug
Weight: 22kDa
Gene: 78428
Format: Lyophilized powder
Target: Wibg is a key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. It acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Wibg interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions.
Alternative names: A030010B05Rik; Pym
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