WDR5 (7B11) Antibody

WDR5 (WD repeat-containing protein 5) belongs to the family of WD-40 repeat protein. It is essential for vertebrate development, Ho, Xenopus/Amphibian, gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithora, Xenopus/Amphibian, (TR, Xenopus/Amphibian,) histone methyltransferase comple, Xenopus/Amphibian,es that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TR, Xenopus/Amphibian,. It is e, Xenopus/Amphibian,pressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.