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Von Willebrand Factor Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 251228

Von Willebrand Factor Antibody

Von Willebrand Factor (VWF) plays a role in the maintenance of hemostasis, where it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matri, Xenopus/Amphibian, and platelet-surface receptor comple, Xenopus/Amphibian, GPIb-I, Xenopus/Amphibian,-V. It also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease (VWD), a group of hemorrhagic disorders in which the von Willebrand factor is either quantitatively or qualitatively abnormal, resulting in altered platelet function. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII and impaired platelet adhesion.

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SPECIFICATIONS

Catalog Number

251228

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Von Willebrand Factor.

Isotype

Rabbit Ig

Accession

P04275

Additional Info

Vwf; vWF; von Willebrand factor; F8VWF; von Willebrand antigen 2; von Willebrand antigen II; VWF

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