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Usp10 (ubiquitin specific peptidase 10 ) Blocking Peptide (the C terminal of Usp10)(100ug)

Usp10 (ubiquitin specific peptidase 10 ) Blocking Peptide (the C terminal of Usp10)(100ug)

This is a synthetic peptide designed for use in combination with anti-Usp10 Antibody (ARP59301_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

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SPECIFICATIONS

Size

100ug

Reactivities

Rat

Format

Lyophilized powder

Presku

AAP59301

Target

Usp10 is a hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. It acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Usp10 does not deubiquitinate MDM2 and deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.

Weight

87kDa

Gene Id

The peptide is characterized by mass spectroscopy

Alternative Names

MGC124997

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