Ultra-LEAF(TM) Purified anti-mouse IL-27 p28

Interleukin IL-27 is a heterodimeric cytokine consisting of EBV-induced gene-3 (EBI3, an IL-12 P40-related protein) and P28 (a newly discovered IL-12 P35-related protein). It is a member of the IL-6/IL-12 cytokine family and mainly produced by antigen-presenting cells, including macrophages and dendritic cells. IL-27 acts on T cells and NK cells. It has been reported that IL-27 drives rapid clonal expansion of naïve CD4+ T cells, promotes Th1 polarization, and IFN-gamma production in synergy with IL-12. The IL-27 induced Th1 differentiation was mediated by rapid and marked up-regulation of ICAM-1/LFA-1 interaction in a STAT1-dependent manner. IL-27 has an anti-inflammatory function by enhancing Th1 cell differentiation, a potent antitumor activity, through CD8+ T cell and NK cell activation and a potential therapeutic role for autoimmune disease by inhibiting Th-17 development. IL-27 mediates its biological effects through its receptor, WSX-1/T cell cytokine receptor (TCCR), which is homologous to the IL-12Rbeta2 subunit. Protein gp130 serves as a functional signal-transducing molecule for IL-27.

Prices direct from BioLegend

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Catalog Number

516912

Size

500 microg

Applications

FC, ICC

Hosts

Mouse

Reactivities

Mouse

Clone

MM27-7B1

Antigen

Mouse IL-27-OVA

Isotype

Mouse IgG2a

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

1 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4. This Ultra-LEAF(TM) solution contains no preservative; handle under aseptic conditions.

Alternative Names

Interleukin-27 p28, IL-27-A, IL-27 subunit alp

Regulatory Status

RUO