Supplier:
Aviva Systems Biology IncorporatedUGT1A6 Antibody (AMM10370A)
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SPECIFICATIONS
Size
100ug
Applications
WB
Hosts
Mouse
Reactivities
Hum
Clone
8C6
Format
Lyophilized powder
Presku
AMM10370A
Target
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.
Weight
58kDa
Gene Id
54578
Isotype
Mouse IgM, k
Alternative Names
GNT1; UGT1; HLUGP; UDPGT; UGT1F; HLUGP1; UGT1A6S; UDPGT 1-6
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