Supplier:
Aviva Systems Biology IncorporatedUchl3 (ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) ) Blocking Peptide (the middle region of Uchl3)(100ug)
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SPECIFICATIONS
Size
100ug
Reactivities
Hum, Mouse
Format
Lyophilized powder
Presku
AAP59298
Target
Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Uchl3 has a 10-fold preference for Arg and Lys at position P3', and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Uchl3 deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Uchl3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response retinal, skeletal muscle and germ cell maintenance. Uchl3 may be involved in working memory and can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.
Weight
26kDa
Gene Id
50933
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