Presku: | AAP58687 |
Size: | 100 ug |
Weight: | 116kDa |
Gene: | 7317 |
Format: | Lyophilized powder |
Target: | UBA1 activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. |
Alternative names: | A1S9; A1S9T; A1ST; GXP1; MGC4781; UBA1A; UBE1; UBE1X |