Reactivities: | Human |
Presku: | AAP30319 |
Size: | 100ug |
Weight: | 134kDa |
Gene: | 7297 |
Format: | Lyophilized powder |
Target: | This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. |
Alternative names: | JTK1 |