Tubulin beta-3 Antibody

Tubulin is the major constituent of microtubules, e, Xenopus/Amphibian,isting as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin is found almost e, Xenopus/Amphibian,clusively in neuronal processes of adult tissues and is therefore an e, Xenopus/Amphibian,cellent marker for neurons. Neuron specific,Porcineosttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated, suggesting that they modulate the interaction of tubulin with microtubule associated proteins. Additionally, beta III tubulin has been found to be highly e, Xenopus/Amphibian,pressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy.