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TrkC Antibody

TrkC Antibody

Cat no: 250897


Supplier: ABBIOTEC
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The Trk family of nerve growth factor receptors includes Trk A, Trk B and Trk C. The prototype member of this gene family, Trk A encodes a 140-kDa cell surface receptor (gp140) e, Xenopus/Amphibian,pressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and embryonic dorsal root ganglia. By comparison, BDNF and to a lesser e, Xenopus/Amphibian,tent, neurotrophin-3 (NT-3), but not NGF, can induce tyrosine phosphorylation of Trk B gp 145. Trk C, the third member of the Trk receptor family, encodes a 140-kDa protein, Trk C gp 140, that is preferentially e, Xenopus/Amphibian,pressed in brain tissue and primarily functions as a receptor for NT-3. An additional component of the Trk receptor comple, Xenopus/Amphibian,, NGFR p 175 , binds to neurotrophic factor with low affinity but is required for efficient signaling.
Catalogue number: 250897
Reactivities: Human, Mouse, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: Q16288
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TrkC.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: NT-3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C; NTRK3; TRKC