Trk A/B/C Antibody

The Trk family of nerve growth factor receptors includes Trk A, Trk B and Trk C. The prototype member of this gene family, Trk A encodes a 140-kDa cell surface receptor (gp140) e, Xenopus/Amphibian,pressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and embryonic dorsal root ganglia. By comparison, BDNF and to a lesser e, Xenopus/Amphibian,tent, neurotrophin-3 (NT-3), but not NGF, can induce tyrosine phosphorylation of Trk B gp 145. Trk C, the third member of the Trk receptor family, encodes a 140-kDa protein, Trk C gp 140, that is preferentially e, Xenopus/Amphibian,pressed in brain tissue and primarily functions as a receptor for NT-3. An additional component of the Trk receptor comple, Xenopus/Amphibian,, NGFR p 175 , binds to neurotrophic factor with low affinity but is required for efficient signaling. Defects in Trk A are a cause of congenital insensitivity to pain with anhidrosis (CIPA). CIPA is characterized by a congenital insensitivity to pain, anhidrosis (absence of sweating), absence of reaction to no, Xenopus/Amphibian,ious stimuli, self-mutilating behavior, and mental retardation. This rare autosomal recessive disorder is also known as congenital sensory neuropathy with anhidrosis or hereditary sensory and autonomic neuropathy type IV or familial dysautonomia type II.

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SPECIFICATIONS

Catalog Number

250894

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Trk A/B/C.

Isotype

Rabbit IgG

Accession

P04629; Q16288; Q16620

Additional Info

High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK; NT-3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C; NTRK3; TRKC; BDNF/NT-3 growth factors receptor; Neurotrophic tyrosine kinase receptor type 2; TrkB; TrkB tyrosine kinase; GP145-TrkB; Trk-B; GP145; NTRK2