TRIAMCINOLONE ACETONIDE

Triamcinolone Acetonide is a more potent type of triamcinolone (synthetic corticosteroid), being about 8 times as effective as prednisone. It is used to treat medical conditions, such as eczema, psoriasis, arthritis, allergies, ulcerative colitis, lupus, sympathetic ophthalmia, temporal arteritis, uveitis, and ocular inflammation, visualization during vitrectomy and the prevention of asthma attacks. Triamcinolone Acetonide has an elimination half-life of 1.5-2.5 hours in Humans [1]. 6Beta hydroxlated and 21-carboxylated metabolites have been reported in humans, rats and dogs for triamcinolone acetonide [1,2]. little or no parent compount was detected in plasma 24 hours after oral administration in humans[2]. plasma binding in humans was 68% [2]. Triamcinolone was not a major metabolite of triamcinolone acetonide in humans, only about 1% of the dose was found in the urine as triamcinolone [3]. 6Beta-H+ydroxytriamcinolone acetonide was the major matabolite in urine of rats, dogs and humans after intra-venous and intra-muscular administration. Hydrolytic cleavage of the acetonide group did not appear to be significant[4].

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