Supplier:
Aviva Systems Biology IncorporatedTP53 Antibody (AMM00024)
Prices direct from Aviva Systems Biology Incorporated
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SPECIFICATIONS
Size
100ug
Applications
IP, WB
Hosts
Mouse
Reactivities
Hum
Format
Lyophilized powder
Presku
AMM00024
Target
Tumor protein p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome
Weight
53kDa
Gene Id
7157
Isotype
Mouse IgG
Alternative Names
P53; LFS1; TRP53; FLJ92943; TP53
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