Human brain tonsilla cerebelli tissue nuclear protein lysate was prepared by isolating the nuclear protein from whole tissue homogenates using a proprietary technique. The human brain tonsilla cerebelli tissue was frozen in liquid nitrogen immediately after excision and then stored at -70˚C. The nuclear protein is provided in a buffer including HEPES (pH7.9), glycerol, NaCl, MgCl2, EDTA, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain tonsilla cerebelli tissue nuclear protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain tonsilla cerebelli tissue nuclear protein is then Western analyzed by histone antibody to confirm that the expression level is consistent with each lot.