Reactivities: | Human |
Presku: | AAP59086 |
Size: | 100ug |
Weight: | 27kDa |
Gene: | 7293 |
Format: | Lyophilized powder |
Target: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. |
Alternative names: | ACT35; CD134; OX40; TXGP1L |