Presku: | AAP30622 |
Size: | 100 ug |
Weight: | 50kDa |
Gene: | 8797 |
Format: | Lyophilized powder |
Target: | This is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adaptor molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. |