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TNFAIP3 Antibody (OAPB00871)

TNFAIP3 Antibody (OAPB00871)

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-alpha, inhibiting NF-kappaB-dependent gene expression, and protecting cells from TNF-alpha-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Presku

OAPB00871

Target

(CT) Tumor necrosis factor alpha-induced protein 3

Alternative Names

TNFAIP3 (CT);Tumor necrosis factor alpha-induced protein 3; A20; OTUD7C; TNFA1P2

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