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TNF beta Recombinant Protein (0.005 mg)

TNF beta Recombinant Protein (0.005 mg)

TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF superfamily of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes incuding cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells. Recombinant human TNF-beta is a secreted 172 amino acid protein (18.6 kDa) which forms an active non-disulfide linked homotrimer structure in solution. Due to glycosylation, TNF-beta has an approximate MW of 19.3 kDa based on SDS-PAGE gel amd Mass Spectrometry.

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SPECIFICATIONS

Size

0.005 mg

Presku

OPPB00178

Alternative Names

Tumor Necrosis Factor-beta; TNFSF1; Lymphotoxin-alpha (LT-alpha)

SUPPLIER INFO

Aviva Systems Biology Incorporated

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