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TMEM59 Antibody (OAPB01211)

TMEM59 Antibody (OAPB01211)

Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Presku

OAPB01211

Target

Transmembrane protein 59

Alternative Names

TMEM59; Transmembrane protein 59; thymic dendritic cell-derived factor 1; liver membrane bround protein; LMBP

SUPPLIER INFO

Aviva Systems Biology Incorporated

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