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TLR5 Antibody

TLR5 Antibody

Cat no: 251565


Supplier: ABBIOTEC
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Toll-like receptor 5 (TLR5) participates in the innate immune response to microbial agents. TLR5 mediates detection of bacterial flagellins. TLR5 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila. Genetic variations in TLR5 are associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a comple, Xenopus/Amphibian, genetic basis.
Catalogue number: 251565
Reactivities: Human, Mouse, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: O60602
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TLR5.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: TLR5; CD285;Toll-like receptor 5; Toll/interleukin-1 receptor-like protein 3; TIL3