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TLR5 Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 251565

TLR5 Antibody

Toll-like receptor 5 (TLR5) participates in the innate immune response to microbial agents. TLR5 mediates detection of bacterial flagellins. TLR5 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila. Genetic variations in TLR5 are associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a comple, Xenopus/Amphibian, genetic basis.\n

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SPECIFICATIONS

Catalog Number

251565

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TLR5.

Isotype

Rabbit Ig

Accession

O60602

Additional Info

TLR5; CD285;Toll-like receptor 5; Toll/interleukin-1 receptor-like protein 3; TIL3

SUPPLIER INFO

ABBIOTEC

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