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TIP47 Antibody (OAPB00435)

TIP47 Antibody (OAPB00435)

Tail-interacting protein (TIP47) is a cytosolic protein essential for the transport of mannose-6-phosphate receptors (MPRs) from endosomes to the trans-Golgi compartments in cells. TIP47 is recruited from the cytoplasm to the late endosomal surface by the Ras-associated protein Rab9 GTPase, enabling it to bind more efficiently to MPR cytoplasmic domains. Recently, it was shown that TIP47 regulates the expression of Rab9, as expression of siRNA to TIP47 in transfected cells dramatically decreased the half-life of the Rab9 protein in addition to stabilizing the subcellular localization of Rab9. At least two isoforms of TIP47 are known to exist.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Rat

Presku

OAPB00435

Target

(CT) golgi, intracellular traffic, rab9

Alternative Names

TIP47 (CT); Tail-interacting protein 47; mannose-6-phosphate receptor binding protein 1; placental protein 17

SUPPLIER INFO

Aviva Systems Biology Incorporated

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