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TIM-4 Antibody (OAPB00414)

TIM-4 Antibody (OAPB00414)

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Presku

OAPB00414

Target

(CT) T cell immunoglobulin and mucin domain containing protein 4

Alternative Names

TIM-4 (CT); T cell immunoglobulin and mucin domain containing protein 4; T cell membrane protein 4; SMUCKLER

SUPPLIER INFO

Aviva Systems Biology Incorporated

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