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Tdp1 (tyrosyl-DNA phosphodiesterase 1 ) Blocking Peptide (the middle region of Tdp1)(100ug)

Tdp1 (tyrosyl-DNA phosphodiesterase 1 ) Blocking Peptide (the middle region of Tdp1)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Tdp1 Antibody (ARP57199_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Mouse
Presku: AAP57199
Size: 100ug
Weight: 64kDa
Gene: The peptide is characterized by mass spectroscopy
Format: Lyophilized powder
Target: Tdp1 is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. It hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. It acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. It has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. It has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Alternative names: 2810481F14Rik; 4921509N21Rik; AI838772; AW493413; E430034L06Rik; SCAN1
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