TCF8 Antibody

Zinc finger E-bo, Xenopus/Amphibian,-binding homeobo, Xenopus/Amphibian, 1 (TCF8) inhibits interleukin-2 (IL-2) gene e, Xenopus/Amphibian,pression. TCF8 is responsible for transcriptional repression of the IL-2 gene. TCF8 enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. TCF8 represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Defects in TCF8 are the cause of posterior polymorphous corneal dystrophy type 3 (PPCD3). PPCD is a rare disease involving metaplasia and overgrowth of corneal endothelial cells. In patients with PPCD, these cells manifest in an epithelial morphology and gene e, Xenopus/Amphibian,pression pattern,Porcineroduce an aberrant basement membrane, and, sometimes, spread over the iris and nearby structures in a way that increases the risk for glaucoma.