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Tau Protein Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250873

Tau Protein Antibody

Tau protein promotes microtubule assembly and stability. Tau is also involved in the establishment and maintenance of neural polarity. The C-terminus domain of Tau binds to a, Xenopus/Amphibian,onal microtubules whereas the N-terminus domain binds to neural plasma membrane components, therefore suggesting that Tau protein functions as a linker between the two. A, Xenopus/Amphibian,onal polarity is predetermined by tau localization in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. PNS-tau is e, Xenopus/Amphibian,pressed in the peripheral nervous system whereas the other isoforms are e, Xenopus/Amphibian,pressed in the central nervous system. Defects in Tau protein are a cause of dementia,Porcinearkinsonism and Alzheimer disease.

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SPECIFICATIONS

Catalog Number

250873

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Tau protein.

Isotype

Rabbit Ig

Accession

P10636

Additional Info

Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL; MTBT1, TAU

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