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Tau Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 251800

Tau Antibody

Microtubule-associated protein tau (tau) promotes microtubule assembly and stability, and is involved in the establishment and maintenance of neuronal polarity. The C-terminus binds a, Xenopus/Amphibian,onal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. A, Xenopus/Amphibian,onal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms play a role in its stabilization. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments,Mouse,ainly composed of hyperphosphorylated forms of tau (PHF-tau or AD P-tau).

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SPECIFICATIONS

Catalog Number

251800

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG1 in 0.1 ml (1 mg/ml) of PBS pH7.4, 2%BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Mouse Monoclonal Antibody

Antigen

Bovine microtubule-associated proteins (MAPs).

Isotype

Mouse IgG1

Accession

P10636

Additional Info

Tau; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; MAPT; MAPTL; MTBT1

SUPPLIER INFO

ABBIOTEC

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