Sumo1 (SMT3 suppressor of mif two 3 homolog 1 (yeast) ) Blocking Peptide (the N terminal of Sumo1)(100ug)

This is a synthetic peptide designed for use in combination with anti-Sumo1 Antibody (ARP30639_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

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SPECIFICATIONS

Size

100ug

Reactivities

Mouse

Format

Lyophilized powder

Presku

AAP30639

Target

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. It is involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. It may also regulate a network of genes involved in palate development.

Weight

11kDa

Gene Id

The peptide is characterized by mass spectroscopy

Alternative Names

GMP1; MGC103203; PIC1; SENTRIN; SMT3; SMT3H3; SMTP3; SUMO-1; Smt3C; Ubl1