Reactivities: | Human |
Presku: | AAP60374 |
Size: | 100ug |
Weight: | 126kDa |
Gene: | 6764 |
Format: | Lyophilized powder |
Target: | This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. |
Alternative names: | DENND2B; HTS1; MGC33090; p126 |