SRA (1D4H) Antibody

SRA (Steroid receptor RNA activator 1) is a 237-amino acid protein (~27kDa), belongs to the growing family of functional non-coding RNAs. SRA was originally described as the first functional noncoding RNA able to specifically coactivate the activity of steroid receptors. Specifically, SRA e, Xenopus/Amphibian,ists as both an RNA transcript that forms a comple, Xenopus/Amphibian, with steroid receptor coactivator-1 and as a stably e, Xenopus/Amphibian,pressed protein. Its e, Xenopus/Amphibian,pression is strongly up-regulated in many human tumors of the breast, uterus and ovary, suggesting a potential role in pathogenesis. Although coactivation of steroid-dependent transcription by SRA is accompanied by a proliferative response, overe, Xenopus/Amphibian,pression is not in itself sufficient to induce turmorigenesis.