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SPRYD2 Antibody (OAPB01316)

SPRYD2 Antibody (OAPB01316)

SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Presku

OAPB01316

Target

SPRY domain-containing protein 2

Alternative Names

SPRY domain-containing protein 2; cardiomyopathy-associated protein 5; CMYA5; dystrobrevin-binding protein 2; DTNBP2; TRIM76

SUPPLIER INFO

Aviva Systems Biology Incorporated

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