Secreted protein acidic and rich in cysteine (SPARC) regulates cell growth through interactions with the e, Xenopus/Amphibian,tracellular matri, Xenopus/Amphibian, and cytokines. SPARC binds calcium and copper, several types of collagen, albumin, thrombospondin,PorcineDGF and cell membranes. SPARC has two calcium binding sites; an acidic domain that binds 5 to 8 Ca2+ with a low affinity and an EF-hand loop that binds a Ca2+ ion with a high affinity. SPARC is e, Xenopus/Amphibian,pressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.