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SPAM1 (sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) ) Blocking Peptide (the C terminal of SPAM1)(100ug)

SPAM1 (sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) ) Blocking Peptide (the C terminal of SPAM1)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-SPAM1 Antibody (ARP64264_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP64264
Size: 100ug
Weight: 58kDa
Gene: 6677
Format: Lyophilized powder
Target: Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative names: HYA1; HYAL1; HYAL3; HYAL5; MGC26532; PH-20; PH20; SPAG15
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