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Soluble IL-6 Receptor alpha Recombinant Protein (0.005 mg)

Soluble IL-6 Receptor alpha Recombinant Protein (0.005 mg)

IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Ralpha and gp130. The IL-6Ralpha chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6Ralpha. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Ralpha alone. IL-6Ralpha is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6Ralpha which consists of only the extracellular domain of the IL-6Ralpha chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6Ralpha is a 37.6 kDa protein consisting of the extracellular domain of the IL-6Ralpha chain (338 amino acid residues).

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SPECIFICATIONS

Size

0.005 mg

Presku

OPPB00153

Alternative Names

soluble IL-6 receptor alpha; B cell stimulatory factor-2; CD126

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