Reactivities: | Human |
Presku: | AAP42148 |
Size: | 100ug |
Weight: | 23kDa |
Gene: | 8651 |
Format: | Lyophilized powder |
Target: | SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. |
Alternative names: | CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3 |