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SOCS-1 Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250862

SOCS-1 Antibody

SOCS family proteins form part of a classical negative feedback system that that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs it inhibits their kianse activity. In vitro, they also supresses Tec protein-tyrosine activity. SOCS1 appears to be a major regulator of interleukin 6 (IL6) and leukemia inihibitory factor (LIF) signaling. SOCS-1 regulates interferon-gamma mediated sensory neuron survival. It is also implicated, through SOCS bo, Xenopus/Amphibian, binding, in ubiquitin-dependent protein degradation. There is high e, Xenopus/Amphibian,pression in thymus, and lower e, Xenopus/Amphibian,pression in lung and spleen.

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SPECIFICATIONS

Catalog Number

250862

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SOCS-1.

Isotype

Rabbit IgG

Accession

O15524

Additional Info

Socs 1; SOCS-1; Suppressor of cytokine signaling 1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; SOCS1

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