SMC1 (5B6) Antibody

SMC1 (Structural maintenance of chromosomes protein 1A) protein is involved in chromosome cohesion during cell cycle and in DNA repair. Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein comple, Xenopus/Amphibian, is required for sister chromatid cohesion. This comple, Xenopus/Amphibian, is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or SMC1. Most of the cohesin comple, Xenopus/Amphibian,es dissociate from the chromosomes before mitosis, although those comple, Xenopus/Amphibian,es at the kinetochore remain. Therefore, SMC1is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair.