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Smad7 Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 251212

Smad7 Antibody

Mothers against decapentaplegic homolog 7 (Smad7) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members. Smad7 has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Smad7 functions as an adapter to recruit SMURF2 to the TGF-beta receptor comple, Xenopus/Amphibian,. Smad7 also acts by recruiting the PPP1R15A-PP1 comple, Xenopus/Amphibian, to TGFBR1, which promotes its dephosphorylation. Genetic variations in Smad7 influence susceptibility to colorectal cancer type 3 (CRCS3). Colorectal cancer consists of tumors or cancer of either the colon or rectum or both.

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SPECIFICATIONS

Catalog Number

251212

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Bov, Prc, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Smad7.

Isotype

Rabbit Ig

Accession

O15105

Additional Info

Smad7; Mothers against decapentaplegic homolog 7; Mothers against DPP homolog 7; hSMAD7; MADH7

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