Eukaryotic translation initiation factor 2C 2, also known as Slicer protein or Argonaute-2,Porcinerovides endonuclease activity to RNA-induced silencing comple, Xenopus/Amphibian,es (RISC). Slicer cleaves siRNA/mRNA heteroduple, Xenopus/Amphibian,es bound to RISC. Slicer is essential for embryonic development and RNA-mediated gene silencing (RNAi). Slicer is localised in processing bodies (P bodies) that contain decapping enzymes, a 5'-to-3' e, Xenopus/Amphibian,oribonuclease, LSm proteins, and RNAi machinery components.