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Slc35D1 Antibody (OAPB00680)

Slc35D1 Antibody (OAPB00680)

The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia. This antibody is predicted to not cross-react with the highly homologous Slc35D2.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, ICC, WB

Hosts

Rabbit

Reactivities

Hum

Presku

OAPB00680

Target

(CT) Solute carrier family 35 member D1

Alternative Names

Slc35D1 (CT); Solute carrier family 35 member D1; UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter

SUPPLIER INFO

Aviva Systems Biology Incorporated

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