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Six1 (sine oculis-related homeobox 1 homolog (Drosophila) ) Blocking Peptide (the N terminal of Six1)(100ug)

Six1 (sine oculis-related homeobox 1 homolog (Drosophila) ) Blocking Peptide (the N terminal of Six1)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Six1 Antibody (ARP38717_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Mouse
Presku: AAP38717
Size: 100ug
Weight: 32kDa
Gene: The peptide is characterized by mass spectroscopy
Format: Lyophilized powder
Target: Six1 is a transcription factor that is involved in regulation of organogenesis. It seems to be required for development of kidney, muscle and inner ear and to be involved in later steps of myogenic differentiation. It may be involved in limb tendon and ligament development. It binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter. It is thought to be regulated by association with Dach and Eya proteins. Six1 acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 phosphatase to the SIX1-DACH1 complex. During myogenesis, Six1 seems to act together with EYA2 and DACH2 .
Alternative names: BB138287
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