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SIRT1 (1F3) Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 253046

SIRT1 (1F3) Antibody

SIRT1 (NAD-dependent deacetylase sirtuin-1) has been found to associate with the tumor suppressor protein p53. SIRT1 binds and deacetylates p53 with specificity for its C-terminal Lys382 residue in response to the upregulation of promyelocytic leukemia protein (PML) nuclear bodies or oncogenic Ras. The deacetylation of p53 SIRT1 has been shown to negatively regulate p53-mediated transcription,Porcinereventing cellular senescence and apoptosis induced by DNA damage and stress. SIRT1 has the closest homology to the yeast Sir2p and is widely e, Xenopus/Amphibian,pressed in fetal and adult tissues, with high e, Xenopus/Amphibian,pression in heart, brain, skeletal muscle and low e, Xenopus/Amphibian,pression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382.

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SPECIFICATIONS

Catalog Number

253046

Size

0.1 ml

Applications

IF, IHC

Reactivities

Hum, Mouse

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of human SIRT1 e, Xenopus/Amphibian,pressed in E. coli.

Isotype

Mouse IgG1

Accession

Q96EB6

Clonality

1F3

Additional Info

NAD-dependent deacetylase sirtuin-1; hSIRT1; SIR2-like protein 1; hSIR2; SIR2L1; SIRT1

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